36th Annual Congress of Turkish Pediatric Surgical Association and 3rd Annual Congress of IPEG-MEC

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Poster - 107

NGAL, CYSTATIN C, ALP, LDH AND ELECTROLYTES AFTER ESWL TREATMENT IN CHILDREN AND ADOLESCENTS WITH UROLITHIASIS

E Milisic*, Z Zvizdic*, A Jonuzi*, N Serdarevic**, L Milisic**
*Clinical center University of Sarajevo, Clinic of pediatric surgery
**Clinical center University of Sarajevo

Introduction: Aim of article was to identify the short-term effects of extracorporeal shock

wave lithotripsy (ESWL) on renal function in children and adolescents with single renal

stones.

Patients and methods: In a 4-year period 30 children were treated for unilateral renal stones

with ESWL. 30 patients (15 boys and 15 girls), met inclusion criteria for the study and

their serum enzymes (alkaline phosphatase, lactate dehydrogenase), cystatin C, serum and

urine electrolytes (sodium, potassium, chloride), and urine neutrophil gelatinase-associated

lipocalin (uNGAL) were tested. Samples were obtained before and on day 1 and day 5

after treatment.

Results: Statistically significant difference was found in the analyzed serum and urine

electrolytes before and after ESWL treatment. Increase of alkaline phosphatase and lactate

dehydrogenase was statistically significant on day 1 after ESWL (p < 0.05) and values

were returned to normal on day 5. Serum cystatin C levels were also significantly

increased during the first four days after ESWL (p < 0.05) and returned to baseline on post-

treatment day 5. There was a statistically significant difference in the levels of uNGAL in

urine before and 24 hours after ESWL (p < 0.05).

Conclusion: On the basis of tests carried out, ESWL is a safe and curative procedure for

the treatment of renal stones in children and adolescents with no evidence of serious

adverse effects on long-term renal function (treatment causes transient functional changes

in renal tubular function in children and adolescents).

NGAL, CYSTATIN C, ALP, LDH AND ELECTROLYTES AFTER ESWL TREATMENT IN CHILDREN AND ADOLESCENTS WITH UROLITHIASIS

E Milisic*, Z Zvizdic*, A Jonuzi*, N Serdarevic**, L Milisic**
*Saraybosna klinik merkezi üniversitesi, Cocuk cerrahisi kliniği
**Saraybosna klinik merkezi üniversitesi

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