WOFAPS 2025 8th World Congress of Pediatric Surgery

Ahmad Eghbali ¹, Khashayar Atqiaee ², Mahdi Parvizi-Mashhadi ², Ali Samady Khanghah ³

¹ pediatric surgery research center research institue for children health ,shahid beheshshti university of medical science Tehran Iran
² Mashhad University of Medical Sciences
³ Ardabil University of Medical Sciences

Purpose: It is not far from the truth that sometimes the onset of a neoplasm is a series of nonspecific syndromes called paraneoplastic syndromes. This group of rare disorders occurs when the immune system, while trying to fight cancer, mistakenly attacks healthy cells and tissues in the body. These disorders are not caused by the direct spread or growth of cancer cells, but rather by substances produced by the tumour or the body's immune response to the tumour.

We aimed to review the paraneoplastic syndromes caused by pediatric Ewing's sarcoma.

Method: We searched the central medical databases of PubMed/Medline, Web of Science, Scopus, ScienceDirect, and Google Scholar, as well as the references of the articles, to collect ten syndromes. The inclusion criteria were full-text available literature and those published for individuals under 19 years old. Autopsy cases made our exclusion criteria.

Results: There were five female cases in front of four males. One study did not mention the sex. The average age of the patients was 15.75 years. The most common syndromes were those with excessive, uncontrolled corticosteroid secretion, with seven cases. The others were cerebral vasculitis, limbic encephalitis and parathormon-independent hypercalcemia, all with a single case.

Conclusion: Although rare, facing a Non-depressible serum cortisol level should raise a suspicion of the presence of a neoplasm, even Ewing's sarcoma