WOFAPS 2025 8th World Congress of Pediatric Surgery

XiaoQi He

Xi'an Children's Hospital

Objective：The main objective of this study is to evaluate the clinical efficacy and safety of transcatheter arterial embolization combined with triamcinolone acetonide sclerotherapy in the treatment of IHs with propranolol resistance

Methods: A total of 32 cases of propranolol-resistant hemangioma(PRIH) admitted to our center from October 2019 to December 2024 were included. PRIH is defined as the continued growth during the proliferation stage or no reduction in size during the post-proliferative stage after at least 4 weeks of regular propranolol treatment at a dose of 2 mg/kg/d. Based on the different treatment methods, the observation group (n=15) underwent transcatheter arterial embolization（TAE）using bleomycin iodized oil emulsion combined with polyvinyl alcohol particles (PVA) followed by intralesional injection of triamcinolone acetonide； while the control group (n=17) was treated with TAE alone. The clinical efficacy, severity scores, and incidence of complications were compared between the two groups.

Results: The total effective rate of clinical treatment in the observation group was higher than that in the control group, the difference was statistically significant (93.3% vs 88.24%,P<0.05). After 6 months of treatment,the hemangioma severity scores of both groups were significantly lower than before treatment, with the observation group (7.39±2.16 vs 1.78±0.45) exhibiting lower scores than the control group (7.58±2.31 vs 2.34±1.05), demonstrating a statistically significant difference (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05), which were primarily minor including fever, swelling, blisters, and pigmentation.

Conclusions：The transcatheter arterial embolization combined with triamcinolone acetonide is a effective and safe therapy for the management of propranolol-resistant hemangiomas and should be further applied in clinic.