WOFAPS 2025 8th World Congress of Pediatric Surgery

İbrahim Yıldırım, Sevim Ecem Ünlü Ballı, OZLEM EKICI CANPOLAT, Gökhan Berktuğ Bahadır, İlhami Sürer

Department of Pediatric Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Türkiye

AIM: The purpose of this study was to investigate effectiveness of pan immun inflammatory value (PIV) as a biomarker and diagnostic tool in surgical necrotising enterocolitis disease (NEC).

METHODS: Between May 2018 and November 2022 all patients whose hospitalized at the newborn intensive care unit (NICU) in our hospital were retrospectively reviewed and. NEC cases were isolated. In this period 793 cases were treated in the NICU and 40 of these diagnosed as NEC. 218 premature babies as a premature control group, also 535 babies as a mature control group were included the study. PIV formulated as a Neutrophil count x Thrombocyte count x Monocyte count / Lymphocyte count.

RESULTS: In our series NEC incidences were found 5.04% in newborn babies and 14.5% in premature newborns. Surgical NEC (Stage III) ratio in NEC patients was 32.5%, and the mortality ratio was 23%. This mortality ratio was two times higher in surgical NEC group when compared with the non-surgical group. In surgical NEC patients, PIV values at postnatal first day statistically significant higher than the stage II and stage I NEC patients. Conversely, at the time of the diagnosis of NEC PIV values were statistically significant lower in surgical NEC group than non-surgical group.

CONCLUSION: Our study demonstrated that higher PIV values on the postnatal first day and lower values at the time of diagnosis can be a predictive tool for diagnosing surgical NEC cases. Lower PIV levels in premature control group vs mature control group can be attributed to immature immun system due to prematurity.