WOFAPS 2025 8th World Congress of Pediatric Surgery

Chunbao Guo

chongqing health center for women and children

Background

Vitamin D plays a crucial role in multiple physiological processes, yet its association with congenital anomalies of the urinary system remains unclear. This study employs the Two-Sample Mendelian Randomization (TSMR) method to investigate the causal relationship between serum 25-Hydroxyvitamin D (25(OH)D) levels and congenital anomalies of the urinary system.

Methods:

The study employed the Two-Sample Mendelian Randomization (TSMR) research method, utilizing summary statistics from Genome-Wide Association Studies (GWAS) for analysis. The data for 25(OH)D were derived from a GWAS involving 417,580 participants, while the outcome variable data came from a 2021 Finnish dataset that included 813 cases and 217,979 controls of European descent. The study employed Inverse Variance Weighting, MR Egger, Weighted Median methods, simple models, and weighted models for TSMR analysis. In the sensitivity analysis, MR Egger and MR PRESSO methods were employed to detect pleiotropy, and Inverse Variance Weighting and MR Egger were used for heterogeneity testing in Cochran's Q statistics.

Results:

The MR analysis found that for each standard deviation increase in the natural log-transformed serum 25(OH)D levels, there was a significant reduction in the risk of congenital anomalies of the urinary system (IVW OR = 2.36; 95% CI: 1.455-3.81; P-value = 0.000492). The results did not display apparent heterogeneity or horizontal pleiotropy.

Conclusion:

The findings of this study support a significant causal relationship between serum 25-Hydroxyvitamin D levels and congenital anomalies of the urinary system.