WOFAPS 2025 8th World Congress of Pediatric Surgery

Emiliana Lia, Trifosa Stella Chowindra, Rizki Diposarosa

Department of Pediatric Surgery, Faculty of Medicine, Padjadjaran University

Purpose: Hirschsprung-associated enterocolitis (HAEC) is an inflammatory bowel disorder resulting from local or systemic immune deficiency with defects in white blood cell function. The purpose of this study was to analyze the relationship between histopathological grade based on the Teitelbaum classification and the severity of enterocolitis.

Methods: This was a retrospective cohort study. Patients <18 years old who were diagnosed with Hirschsprung's disease associated with enterocolitis by looking at age, gender, Hirschsprung’s family history, histopathological grade, and HAEC grade.

Results: In the 2022-2023 period, there were 38 patients, with the most common age being < 1 month old (47.4%) with a dominant distribution in male gender (71.1%), Hirschsprung’s family history was found in 21 patients (55.3%), and Trisomy 21 was found in 47.4%. The most histopathological findings for HAEC were grade 0 (92.1%), and the most HAEC grade findings were grade 1 (57.8%). A significant relationship was found between gender (p=0.029), Hirschsprung’s family history (p=0.002), and Trisomy 21 (p=0.001) with the severity of enterocolitis. The histopathological grade based on the Teitelbaum classification was related to the severity of enterocolitis (p=0.044).

Conclusion: The most histopathological grade of HAEC is grade 0, with no abnormalities found on histopathological examination, and the most degree of HAEC is grade 1. The more severe the grade of HAEC, the more severe the histopathological grade.