WOFAPS 2025 8th World Congress of Pediatric Surgery

Kaloyan Georgiev, Krasimira Kalinova

Faculty of Medicine, Trakian University, Bulgaria

Background

Since acute appendicitis in children can be treated differently, we investigated the combined diagnostic modelof interleukin-6, Procalcitonin and Ferritin for acute uncomplicated appendicitis, acute complicated appendicitis and a control group .

Materials and Methods: A retrospective study included patients who underwent appendectomy for acute appendicitis over a period of five years. In this prospective single-centered cohort study for IL-6, Procalcitonin and Ferritin in serum were assayed preoperatively. Children aged to 18 years old were divided into three groups: AcA, AuA, and Ctr.The predictive values of biomarkers were evaluated by receiver operating characteristics.

Results: A total of 152 participants were enrolled, including AcA (n = 54), AuA (n = 40) and Ctr (n = 58). The combined diagnostic model was established and showed that combined diagnostic model AA vs Ctr reached a sensitivity of 90.3 %, a specificity of 90.8 % and an area under the curve of 0.86 (p<0.001). The combined diagnostic model AcA vs AuA reached a sensitivity of 60 %, a specificity of 70 %. A receiver operating characteristic curve was constructed to define the best score performance

Conclusion: The combined diagnostic model of serums predictors at the emergency department may provide a new approach for differentiating between AcA , AuA, and other causes of abdominal pain.