EN
TÜRKÇE
Poster - 77
The Absence of Ganglion Cells in Primary Obstructive Megaureter
Mridul Joshi, Suman Bikram Adhikari
Kanti Children's Hospital, Maharajgunj, Kathmandu
Background:
Primary obstructive megaureter (POM) is a prevalent cause of congenital hydroureteronephrosis, characterized by the dilation of the ureter proximal to a narrowing at the vesicoureteral junction (VUJ).
Objective:
This study investigates the hypothesis that the absence of ganglion cells in the distal ureter contributes to the pathogenesis of POM, leading to impaired peristalsis and functional obstruction.
Methods:
A prospective, observational study was conducted at Kanti Children’s Hospital, involving 16 patients diagnosed with primary megaureter. Distal ureter biopsies were collected intraoperatively and examined using hematoxylin and eosin (H&E) staining to identify the presence of ganglion cells.
Results:
All 16 patients (100%) demonstrated complete absence of ganglion cells in the distal ureter. Patients ranged in age from 9 to 132 months (median age: 36 months), with a male-to-female ratio of 1.7:1. Right-to-left side involvement ratio was 1:3.
Conclusions:
Absence of ganglion cells may contribute to persistent functional obstruction in POM. Early surgical intervention may be warranted in such cases. Further research with advanced histological methods is necessary.